2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178665
    DMTr-2',2'-diFluoro-dA(Bz)-3'-CE-phosphoramidite
    DMTr-2',2'-diFluoro-dA(Bz)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2',2'-diFluoro-dA(Bz)-3'-CE-phosphoramidite
  • HY-W1119956
    5’-(E)-VPG Phosphoramidite
    5'-(E)-VPG Phosphoramidite (5'(E)-VP-2'-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent used to synthesize biologically stable oligonucleotides. 5'-(E)-VPG Phosphoramidite (POM) carries a VP protecting group and can be coupled to the target oligonucleotide at the 5' end via solid-phase synthesis. The modified oligonucleotide is then constructed through oxidation and deprotection steps. 5'-(E)-VPG Phosphoramidite is suitable for RNAi and viral replication research.
    5’-(E)-VPG Phosphoramidite
  • HY-145976
    m7GpppGpG
    m7GpppGpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppGpG prevents premature degradation by 5′-exonucleases and recruits proteins required for pre-mRNA splicing, mRNA transport and initiation of protein biosynthesis.
    m7GpppGpG
  • HY-107025
    Cf1743
    		99.44%
    Cf1743 is a potent anti-varicella-zoster virus (VZV) bicyclic nucleoside analogue. Cf1743 has antiviral activity, with an IC50 of 3.3 μM for VZV thymidine kinase (TK).
    Cf1743
  • HY-178539
    DMTr-2'-O-Me-rG(iBu)-3'-(L)-DPSE-phosphoramidite
    DMTr-2'-O-Me-rG(iBu)-3'-(L)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-rG(iBu)-3'-(L)-DPSE-phosphoramidite
  • HY-171519
    2′-O-MOE-CMP
    2′-O-MOE-CMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-O-MOE-CMP
  • HY-137692A
    2',3'-Dideoxyuridine-5'-O-1-thiotriphosphate tetrasodium
    2',3'-Dideoxyuridine-5'-O-(1-thiotriphosphate) (ddUTPαS) tetrasodium is a sulfur-containing nucleoside triphosphate derivative.
    2',3'-Dideoxyuridine-5'-O-1-thiotriphosphate tetrasodium
  • HY-N15369
    3′-GMP
    3′-GMP is a nucleotide that can be isolated from the tubers of Jerusalem artichoke (Helianthus tuberosus L.).
    3′-GMP
  • HY-178666
    2'-O-Propargyl-rC(Ac)
    2'-O-Propargyl-rC(Ac) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-O-Propargyl-rC(Ac)
  • HY-178527
    DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-phosphoramidite
    DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-rA(Bz)-3'-(L)-DPSE-phosphoramidite
  • HY-177372
    saRNA negative control
    saRNA negative control is a saRNA and can be used as a negative control.
    saRNA negative control
  • HY-178529
    DMTr-2'-O-propyl-rG(iBu)-3'-CE-phosphoramidite
    DMTr-2'-O-propyl-rG(iBu)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-propyl-rG(iBu)-3'-CE-phosphoramidite
  • HY-178622
    3'-O-Azidomethyl-CTP
    3'-O-Azidomethyl-CTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-Azidomethyl-CTP
  • HY-178635
    DMTr-2'-O-propyl-rC(Bz)-3'-CE-phosphoramidite
    DMTr-2'-O-propyl-rC(Bz)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-propyl-rC(Bz)-3'-CE-phosphoramidite
  • HY-W1119946
    (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate
    (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate is a laurate derivative with a dimethoxytrityl (DMT) protecting group and a 3-pyrrolidinol structure. (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate can be used for oligonucleotide modification or as a lipid-soluble delivery vehicle.
    (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate
  • HY-178568
    DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite
    DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite
  • HY-178567
    m7ITP
    m7ITP is a monomeric raw material that can be used for nucleic acid synthesis.
    m7ITP
  • HY-178686
    DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-phosphoramidite
    DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-phosphoramidite
  • HY-W881216
    (S)-GNA-T-phosphoramidite
    (S)-GNA-T-phosphoramidite (Compound 4) is a phosphoramidite compound that can be used for the synthesis of oligonucleotides.
    (S)-GNA-T-phosphoramidite
  • HY-178593
    5'-OH-(2'OMe-U)pU
    5'-OH-(2'OMe-U)pU Ammonium Salt is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-OH-(2'OMe-U)pU